The second of Thomas Meighan's three 1927 vehicles, We're All Gamblers was also the first of two collaborations between Meighan and director James Cruze. Based on Lucky Sam McCarver, a play by Sidney Howard, the story concerns a refugee of the Lower East Side who rises to the uppermost rungs of the nightclub world, all for the sake of a "dame." Boxer Sam McCarver (Meighan) falls in love with society girl Carlotta Asche (Mariette Mische).

"It's your loss if you miss it!"