The title represents the hopeful, ambitious students at a hospital training school and is primarily a story of the stern discipline and laborious physical and mental toil they endure in order to become nurses and join the White Parade. It is told mainly through the character of June Arden who finds romance with Ronald Hall III on the way, with side stories of the other girls who find failure, success, laughs and tears on the way.

"This story was never told! …of girls nobody knows!"