During the Edo period, an incident occurred in a certain castle town where young samurai were weakened and died one after another. Suspicious, the chief retainer investigates and discovers that a beautiful princess named Tsukihime is giving her body to the young samurai every night and spreading her own disease. The chief retainer trapped Tsukihime in a pot with the help of a monk who used his magic powers and sank her into a pond, but when a female ninja servant came to rescue the princess, a huge earthquake struck. The princess and the kunoichi travel forward in time. There is a lot of fuss about AIDS in the streets as a strange disease of modern times. At one company, a situation was occurring in which employees were collapsing one after another. Tsukihime and Kuichi appear and cause a huge commotion.

"What is this? Ancient AIDS! From the distant past, there was a disease that plagued men's lower bodies and a slutty woman."